Extracellular CIRP as an endogenous TREM-1 ligand to fuel inflammation in sepsis
نویسندگان
چکیده
منابع مشابه
TREM-1 as a potential therapeutic target in neonatal sepsis.
OBJECTIVE Bacterial sepsis in neonates is associated with elevated morbidity and mortality. A role for the pro-inflammatory Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) is suspected in the innate immune response to bacteria, but little is known about its activities in infants. To begin exploring the feasibility of treating neonatal sepsis by blocking leukocyte TREM-1, we compared T...
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Sterile or non-infectious inflammation and severe infection are accompanied by very similar events. Damage (or danger)-associated molecular patterns and pathogen-associated molecular patterns trigger the release of inflammatory mediators and modulate the expression of cell surface receptors. The increased expression on monocytes and neutrophils of triggering receptor expressed on myeloid cells ...
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The triggering receptor expressed on myeloid cells 1 (TREM-1) plays an important role in the innate immune response related to severe infections and sepsis. Modulation of TREM-1-associated activation improves the outcome in rodent models for pneumonia and sepsis. However, the identity and occurrence of the natural TREM-1 ligands are so far unknown, impairing the further understanding of the bio...
متن کاملPrognostic value and therapeutic potential of TREM-1 in Streptococcus pyogenes induced sepsis Running title: TREM-1 in S. pyogenes severe sepsis
The triggering receptor expressed on myeloid cells (TREM-1) is a surface molecule expressed on neutrophils and macrophages, which has been implicated in the amplification of the inflammatory responses triggered during infection. In the present study we have investigated the clinical significance of TREM-1 in Streptococcus pyogenes severe sepsis in both experimentally infected mice as well as in...
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Triggering receptor expressed on myeloid cells (TREM)-1 is an orphan receptor implicated in innate immune activation. Inhibition of TREM-1 reduces sepsis in mouse models, suggesting a role for it in immune responses triggered by bacteria. However, the absence of an identified ligand has hampered a full understanding of TREM-1 function. We identified complexes between peptidoglycan recognition p...
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ژورنال
عنوان ژورنال: JCI Insight
سال: 2020
ISSN: 2379-3708
DOI: 10.1172/jci.insight.134172